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Target intelligence / Profile preview
Katanin p60 ATPase-containing subunit A1 (KATNA1)
- Target
- KATNA1
- Molecular classification
- Enzyme, Microtubule severing protein, AAA family (ATPases Associated with diverse cellular Activities)
01
Overview
Katanin p60 ATPase-containing subunit A1 (KATNA1) is a microtubule-severing enzyme that comprises the catalytic component of the katanin complex and belongs to the AAA family of ATPases. It acts by binding and severing microtubules in an ATP-dependent manner, promoting rapid reorganization of the cytoskeleton during processes such as mitosis and neuronal migration[1][2][5]. KATNA1 is essential for the regulation of microtubule length, stability, and organization, and thus is involved in critical aspects of cell division, development, and neurobiology[1][3][5].
- Other names
- katanin catalytic subunit A1KATNA1katanin p60 subunit A1p60 kataninkatanin p60 ATPase-containing subunit A1katanin p60 (ATPase-containing) subunit A1
02
Biological functions
Microtubule severingMicrotubule cytoskeleton organizationNeuron migrationCell cycle progression
03
Disease associations
Neurodegenerative disease (implicated by function in neural microtubule regulation)Cancer (potentially due to role in cell division)Other (general involvement in diseases of cytoskeletal dysregulation)
04
Safety considerations
Disruption of katanin function may affect cell division, neuronal development, and axonal integrity, but specific safety concerns for therapeutic targeting are not established.
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