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Katanin regulatory subunit B1-like 1 (KATNBL1)
- Target
- KATNBL1
- Molecular classification
- Other (Microtubule-associated protein, regulatory subunit), not classified as receptor, enzyme, ion channel, transporter, or transcription factor
01
Overview
Katanin regulatory subunit B1-like 1 (KATNBL1) is a protein-coding gene that encodes a regulatory subunit of the katanin microtubule-severing complex[1][6]. Katanin complexes are heterodimers consisting of a catalytic A subunit with ATPase/severing activity and a regulatory B subunit[3]. KATNBL1 is a B-like regulatory subunit that modulates the severing activity of the catalytic subunit (such as KATNAL1) during mitosis, specifically localizing to spindle poles. It participates in positive regulation of microtubule organization and cytoskeleton architecture, particularly during cell division[1][6]. Unlike the canonical B subunit KATNB1, KATNBL1 is less widely conserved evolutionarily, suggesting a regulatory role unique to vertebrates[3]. There is no current evidence that KATNBL1 is a therapeutic drug target, nor are there drugs, biomarkers, or specific diseases directly linked as a result of its modulation[1][6].
- Other names
- KATNB1-like protein 1C15orf29FLJ22557Katanin p80 subunit B-like 1KTBL1_HUMAN
02
Mechanism of action
None reported (no drugs known to target KATNBL1)
03
Biological functions
Microtubule bindingCytoplasmic microtubule organizationPositive regulation of cytoskeleton organizationRegulation of microtubule-severing activitySpindle pole organization during mitosis
04
Disease associations
Limited evidence—associations with Epithelioid leiomyosarcoma and Myxoid leiomyosarcoma (based on gene/disease database, not direct evidence of causal/pathogenic role)
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