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KCNIP4 intronic transcript 1 (KCNIP4-IT1)

Target: KCNIP4-IT1
Molecular classification: Long non-coding RNA (lncRNA)

Overview

KCNIP4 intronic transcript 1 (KCNIP4-IT1, or 38A) is a human long non-coding RNA transcribed by RNA polymerase III from intron 1 of the KCNIP4 gene. It acts in *antisense* configuration relative to the KCNIP4 pre-mRNA and regulates alternative splicing of KCNIP4 transcripts. Upregulation of KCNIP4-IT1 (38A) drives the production of KCNIP4 isoform IV, which alters potassium channel inactivation and disrupts the interaction with the γ-secretase complex, leading to changes in amyloid precursor protein processing and increased production of neurotoxic β-amyloid species. Its expression is increased by inflammatory signals and is upregulated in the brains of patients with Alzheimer's disease, bridging a molecular link between inflammation, alternative splicing, and neurodegeneration

Other names: 38AUM9-5NCRNA00099non-coding transcript UM9(5)UM9(5)KCNIP4 intronic transcript 1 (non-protein coding)

Biological functions

Regulation of alternative splicing of KCNIP4 pre-mRNAModulation of potassium channel function (indirect, via regulation of KCNIP4 protein isoforms)Potential role in neuronal excitabilityLink between inflammation and alternative splicing in neurodegeneration

Disease associations

Neurodegenerative disease (notably, implicated in Alzheimer's disease through regulation of amyloid precursor protein processing and β-amyloid secretion)Other (possible generalized roles in brain physiology and disease via modulation of KCNIP4 splicing)

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