KDEL endoplasmic reticulum protein retention receptor 3 (KDELR3)

KDEL endoplasmic reticulum protein retention receptor 3 (KDELR3) is a seven-transmembrane receptor localized to the endoplasmic reticulum and Golgi apparatus. It recognizes and binds the C-terminal KDEL sequence (Lys-Asp-Glu-Leu) of ER-resident soluble proteins, mediating their retrieval from the cis-Golgi and return to the ER, which is crucial for ER protein homeostasis. KDELR3 belongs to a conserved receptor family with homologs KDELR1 and KDELR2. KDELR3 expression is regulated by cellular stress (UPR) and is involved in protein synthesis, folding, autophagy, and lipid metabolism. Pathologically, altered KDELR3 expression is implicated in a range of cancers (glioma, melanoma, renal, prostate, and hepatic cancers) and is associated with prognosis, metastatic potential, and immune cell infiltration. KDELR3 is also a potential diagnostic and prognostic biomarker for glioma and atherosclerosis. There are currently no approved drugs directly targeting KDELR3, and it is not established as a druggable target in clinical practice.

Other names

ER lumen protein-retaining receptor 3KDELR3ERD23ERD2L3KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3KDEL receptor 3

Not established for drugs, as there are currently no known drug interactions; biologically, the receptor mediates retention and retrieval of ER-resident proteins via KDEL sequence binding and regulates ER-Golgi transport