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Target intelligence / Profile preview
Kelch domain containing 8B (KLHDC8B)
- Target
- KLHDC8B
- Molecular classification
- Scaffold protein (Kelch family), BTB (Broad complex, Tramtrack and Bric-à-brac)/POZ (poxvirus and zinc finger) domain protein, BBK (BTB, BACK, kelch) superfamily, Protein involved in E3 ubiquitin ligase complexes (suggested)
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Overview
Kelch domain containing 8B (KLHDC8B) encodes a protein with essential roles in the final separation of daughter nuclei during cell division, specifically ensuring accurate cytokinesis and chromosomal stability[2][3][5]. The protein is localized to the Golgi apparatus in non-dividing cells but translocates to the spindle apparatus during mitosis[1]. Structurally, it belongs to the BBK (BTB, BACK, kelch repeat) superfamily, serving functions as a scaffold for protein interactions, potentially in ubiquitin ligase complexes[1][6]. Deficiency of KLHDC8B leads to mitotic errors, centrosomal amplification, and aneuploidy[2][3][5], and its genetic variants are implicated in classic Hodgkin lymphoma[5]. No approved drugs directly target KLHDC8B, but its roles in cell division and genomic integrity suggest significant therapeutic and research potential[3][5].
- Other names
- Kelch domain-containing protein 8BKLD8BKBTBD8 (Kelch repeat and BTB (POZ) domain containing 8)
02
Mechanism of action
null
03
Biological functions
Cell division and cytokinesisMaintenance of chromosomal stabilityProtection against mitotic errors, centrosomal amplification, and aneuploidyMidbody function during late stages of cell divisionProtein–protein interactions (scaffold for ubiquitination and degradation per Kelch family)
04
Disease associations
Classic Hodgkin lymphomaHodgkin’s lymphoma (general association)Potentially other proliferative disorders (no strong evidence yet)
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Safety considerations
Potential off-target effects due to involvement in cell divisionTherapeutic targeting may risk chromosomal instability and related cytotoxicity
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