Kelch domain-containing protein 2 (KLHDC2)

KLHDC2 is a substrate-recognition component of the Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, involved in the degradation of proteins ending with specific C-terminal sequences, such as diglycine (Gly-Gly). It plays a crucial role in the ubiquitin-proteasome pathway, particularly through the recognition of C-end degrons in aberrant or truncated proteins. This information is based on the role of KLHDC2 in protein degradation and its involvement in processes like ubiquitination. KLHDC2 acts as part of the DesCEND pathway, targeting proteins with specific C-terminal motifs for degradation. Its role in cancer, particularly in hepatocellular carcinoma, is reflected in its alternative names.

Other names

HCLP-1LCPHepatocellular carcinoma-associated antigen 33Host cell factor homolog LCPHost cell factor-like protein 1

Recognition of C-end degrons leading to ubiquitination and degradation of target proteins