Kelch domain-containing protein 7A (KLHDC7A)

Kelch domain-containing protein 7A (KLHDC7A) is a member of the Kelch domain-containing protein family, a group of proteins that typically function as adaptors in protein–protein interactions, often facilitating the ubiquitination and degradation of substrates via cullin–RING E3 ubiquitin ligase complexes[3][4]. KLHDC7A is predicted to localize to nuclear speckles and possibly membranes, with expression seen in multiple tissues, especially the kidney[1][4]. Although direct functional assignment is limited, KLHDC7A has been implicated in vascular disease through genetic association studies (notably diabetic retinopathy), in tissue remodeling diseases (such as Dupuytren’s contracture), and as a possible biomarker for intracranial aneurysm[2]. The precise biological mechanisms remain unclear, but it is believed KLHDC7A may play roles in regulating vascular integrity, extracellular matrix signaling, and cell differentiation/proliferation through its putative adaptor activity in ubiquitin-mediated protein degradation[2][4]. No currently approved drugs target KLHDC7A directly, and its status as a direct therapeutic target remains unproven.

Other names

FLJ38753kelch domain containing 7AKLHDC7A