Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Kelch-like ECH-associated protein 1 (KEAP1)
- Target
- KEAP1
- Molecular classification
- Transcription factor regulator, E3 ubiquitin ligase adaptor
01
Overview
KEAP1 is a key regulatory protein that functions as an adaptor subunit of Cullin3-based E3 ubiquitin ligase complexes. It primarily regulates the transcription factor NRF2, promoting its degradation under normal conditions and releasing it under oxidative/electrophilic stress, leading to activation of antioxidant response element (ARE)-driven genes.
- Other names
- INrf2
02
Mechanism of action
Inhibition of KEAP1 to activate NRF2
03
Biological functions
Regulation of NRF2 activityUbiquitinationProteasomal degradationAntioxidant response regulationRedox homeostasisAutophagy regulation
04
Disease associations
CancerChemoresistanceOxidative stress-related diseases
05
Safety considerations
Constitutive activation of NRF2 can promote tumorigenesis and chemoresistanceLoss-of-function mutations impair antioxidant defenses
Beyond the preview
Go deeper on Kelch-like ECH-associated protein 1 (KEAP1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Kelch-like ECH-associated protein 1 (KEAP1).