Kelch-like family member 9 (KLHL9)

Kelch-like family member 9 (KLHL9) is a substrate-specific adaptor protein within the cullin 3-based E3 ubiquitin-protein ligase complex, mediating the ubiquitination and subsequent proteasomal degradation of specific substrates, including Aurora B kinase[1][4]. This protein contains a BTB/POZ domain for protein-protein interaction, a BACK domain, and six C-terminal kelch repeats, which together modulate mitotic progression and cytokinesis through regulation of spindle midzone integrity[1][4]. KLHL9 is expressed widely, with prominent expression in skeletal muscle and involvement in muscle maintenance; mutations cause early-onset distal myopathy[4]. KLHL9, like other KLHL family members, is mechanistically involved in proteostasis via targeting proteins for degradation, but is not typically considered a classical pharmacological therapeutic target (e.g., receptor, enzyme, transporter)[1][3][4]. There is limited evidence for direct drug interaction or its use as a clinical biomarker.

Other names

Kelch-like protein 9KIAA1354FLJ13568