Kelch-like protein 10 (KLHL10)

Kelch-like protein 10 is a member of the BTB-Kelch superfamily containing an N-terminal BTB/POZ domain, a BACK domain, and six C-terminal Kelch repeats[3][7][8]. It is primarily expressed in testicular tissue and functions as an adaptor protein within a CUL3-dependent E3 ubiquitin ligase complex during spermatogenesis, targeting specific proteins for ubiquitination and proteasomal degradation[2][3][8]. Mutations in the KLHL10 gene are associated with oligozoospermia and male infertility[3][7]. There is currently no evidence that it functions as a therapeutic target (such as a receptor, enzyme, transporter, or transcription factor), nor are there any drugs targeting or modulating KLHL10 in clinical use[2][3][8]. The gene encoding this protein is located on human chromosome 17[7]. Kelch-like protein 10's closest paralog is KLHL2[3]. While the broader KLHL protein family is involved in ubiquitin-mediated protein degradation and associated with human diseases (including cancers and some Mendelian diseases)[1], KLHL10's primary clinical relevance is in reproductive health. Standardized identifiers include HGNC:18829, NCBI Gene:317719, and UniProtKB:Q6JEL2[3][8].

Other names

KLHL10Kelch like family member 10