Kelch-like protein 11 (KLHL11)

Kelch-like protein 11 (KLHL11) is a member of the KLHL family of proteins, which are characterized by the presence of BTB/POZ, BACK, and Kelch domains that facilitate scaffolding and protein–protein interactions[1][4]. KLHL11 serves as a substrate-specific adapter for cullin-3–based E3 ubiquitin ligase complexes, promoting the ubiquitination and subsequent degradation of target proteins[4]. Members of this protein family are evolutionarily conserved and play important roles in cellular processes including actin cytoskeleton organization, protein turnover, and regulation of intracellular signaling pathways[1][2]. Mutations in certain KLHL family proteins, including KLHL11, have been implicated in Mendelian diseases and various cancers, highlighting the clinical significance of this family[1][2]. KLHL11 is the most ancient member of the human KLHL family, and its precise physiological substrates and disease associations remain active areas of research[1][2]. If you are seeking a therapeutic target, KLHL11 is classified as an E3 ubiquitin ligase adapter, but as of now, no drugs are known to directly target it or use it as a primary biomarker. It is a recognized target in molecular and disease studies, especially around cancer[1][2][4].

Other names

KLHL11Kelch-like family member 11

E3 ubiquitin ligase substrate adapter (mediates ubiquitination and degradation of client proteins via the cullin-3 complex)