Kelch-like protein 15 (KLHL15)

Kelch-like protein 15 (KLHL15) is a member of the kelch-like family of substrate adaptors for Cullin3-based E3 ubiquitin ligase complexes, characterized by an N-terminal BTB/POZ domain, a BACK domain, and C-terminal kelch repeats[1][3][4][5]. KLHL15 plays a role in protein homeostasis by targeting specific substrate proteins (such as the phosphatase PP2A subunit PPP2R5B and the DNA end-resection factor CtIP/RBBP8) for ubiquitination and proteasomal degradation, thereby regulating cytoskeletal organization, the DNA damage response, and neural development[1][3][4][7]. Disruption of KLHL15 function or mutations in KLHL15 have been linked to X-linked intellectual disability and developmental brain anomalies[1][3]. Emerging evidence also implicates KLHL15 in oncogenesis and as a putative cancer biomarker, particularly in the context of esophageal carcinoma[1]. KLHL15 is widely expressed in human tissues, reflecting its fundamental role in cellular homeostasis[2][8]. Notes: - This is not a traditional therapeutic target (e.g., receptor, druggable enzyme, transporter), so `is_target` is set to false since no drugs are reported to modulate KLHL15 directly per current knowledge or database results[3][4][6][7]. - `interacting_drugs` and `mechanism_of_action` are set to null, as there is no evidence of KLHL15 being directly targeted by pharmacological agents in public databases. - KLHL15 is best described as a substrate adaptor in ubiquitin ligase complexes and a pleiotropic regulator, with crucial roles in proteostasis, DNA repair, and neural development[1][3][4][7].

Other names

kelch like family member 15KIAA1677HEL-S-305XLID103epididymis secretory protein Li 305epididymis secretory sperm binding proteinKLH15_HUMAN