Kelch-like protein 2 (KLHL2)

Kelch-like protein 2 (KLHL2) is a member of the Kelch-like protein family, acting as a substrate-specific adapter of a BTB-CUL3-RBX1 (BCR) E3 ubiquitin ligase complex. KLHL2 mediates the ubiquitination and subsequent proteasomal degradation of specific protein substrates, including WNK kinases (WNK1, WNK3, WNK4) and NPTXR. It is involved in reorganization of the actin cytoskeleton and promotes the growth of cell projections in oligodendrocyte precursor cells. It is primarily a cytoskeletal and regulatory protein, not a classical receptor or enzyme target, but is increasingly recognized as relevant for cell biology and disease. Its main known disease association is with pseudohypoaldosteronism.

Other names

KLHL2Kelch like family member 2ABP-KELCHMAVMayvenactin-binding protein Mayvenkelch-like 2kelch-like family member 2