Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Kelch-like protein 21 (KLHL21)
- Target
- KLHL21
- Molecular classification
- Other (Kelch-like protein), E3 ubiquitin ligase adaptor
01
Overview
Kelch-like protein 21 (KLHL21) is a member of the Kelch-like protein family that functions primarily as a substrate-specific adapter for the Cullin 3-based E3 ubiquitin-protein ligase complex, contributing to protein ubiquitination and the regulation of chromosome passenger complex localization at the spindle midzone during mitosis[3][1]. KLHL21 is essential for cytokinesis and correct cell division, as well as negatively regulating the activation of IκB kinase-β (IKKβ), thereby modulating NF-κB signaling[1]. Dysregulated expression of KLHL21 promotes cancer cell proliferation, migration, and invasion, particularly in hepatocellular carcinoma, where it may serve as a prognostic biomarker and potential therapeutic target[2][3].
- Other names
- Kelch-like family member 21KLHL21KIAA0469KIAA0469 proteinkelch-like protein 21
02
Biological functions
Cell cycleCytokinesisUbiquitinationRegulation of NF-κB signalingChromosome passenger complex localization
03
Disease associations
Cancer (notably hepatocellular carcinoma)Combined oxidative phosphorylation deficiency 8
04
Biomarkers
Expression of KLHL21 as a prognostic marker in hepatocellular carcinoma[2]
Beyond the preview
Go deeper on Kelch-like protein 21 (KLHL21).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Kelch-like protein 21 (KLHL21).