Kelch-like protein 23 (KLHL23)

Kelch-like protein 23 (KLHL23) is an E3 ubiquitin ligase substrate adaptor protein encoded by the KLHL23 gene on chromosome 7 and is a member of the Kelch-like family, characterized by a BTB/POZ domain, a BACK domain, and a Kelch repeat domain[2][4]. Proteins in this family participate in substrate recognition for Cullin3-RBX1 E3 ubiquitin ligase complexes, playing key roles in the ubiquitin-proteasome system for protein homeostasis and degradation[2][1]. KLHL23 regulates diverse cellular processes including cytoskeleton reorganization, cell proliferation, and apoptosis, likely through targeting specific proteins such as actin for ubiquitination and degradation[2][5]. In cancer biology, KLHL23 shows differential expression across multiple tumor types, with upregulation associated with poorer prognosis in hepatocellular carcinoma, low-grade glioma, and other tumors, and its molecular alterations (like mutations, copy number variation, and promoter methylation) correlate with clinical outcomes[2]. KLHL23 expression has also been proposed as a biomarker for prognosis and treatment responsiveness in various cancers, but no clinically approved drugs directly target this protein as of the current knowledge[2][5].

Other names

Kelch-like family member 23MGC2610FLJ37812MGC22679DITHPPHOSPHO2-KLHL23

none reported (no specifically approved/investigational drugs with known mechanism targeting KLHL23 as the primary target)