Kelch-like protein 25 (KLHL25)

Kelch-like protein 25 (KLHL25) is a substrate-specific adapter in CUL3-based E3 ubiquitin ligase complexes, facilitating the ubiquitination and proteasomal degradation of target proteins. It plays a role in translation homeostasis and regulation of lipid synthesis via its modulation of ACLY, a key enzyme in fatty acid metabolism. KLHL25 is implicated in the differentiation of regulatory T cells by reprogramming fatty acid metabolic pathways. Like other Kelch-like family members, it contains a BTB domain, a BACK domain, and multiple Kelch motifs that mediate protein-protein interactions. Dysregulation of KLHL25 and related family members has been linked to cancer and other metabolic or genetic diseases, although specific roles and therapeutic applications are still under investigation[1][3][5][6][7].

Other names

KLHL25Kelch-like family member 25Ectoderm-neural cortex protein 2

Targeting the ubiquitin-proteasome pathway via modulation or inhibition of substrate recognition/adaptor activity