Kelch-like protein 28 (KLHL28)

Kelch-like protein 28 (KLHL28) is a soluble, cytoplasmic adaptor protein encoded by the KLHL28 gene. It belongs to the larger kelch-like protein family, characterized by a conserved set of motifs: BTB/POZ domain (protein binding/dimerization), a BACK domain (putative structural importance), and multiple kelch domains forming a β-propeller fold[1][3]. KLHL28 is broadly expressed, with elevated levels in brain and heart tissue, and interacts with numerous proteins forming part of the E3 ubiquitin ligase complex—most prominently Cullin-3 (CUL3)[1]. This complex is critical for protein turnover via ubiquitin-mediated degradation. KLHL28 dysregulation has been linked in genomic studies to increased risk of cancer, hypertension, and epilepsy[1][2][3]. Unlike classical receptors or enzymes targeted by drugs, KLHL28 serves mostly as a substrate adaptor within protein degradation pathways. Its clinical significance is largely based on its genetic, molecular, or functional involvement in disease states rather than as a direct therapeutic target[1][2][3].

Other names

Kelch-like family member 28KLHL28BTBD5FLJ20081BTB/POZ domain-containing protein 5kelch-like 28