Kelch-like protein 29 (KLHL29)

Kelch-like protein 29 (KLHL29) is a member of the evolutionarily conserved Kelch-like (KLHL) family of proteins, all of which typically contain a BTB/POZ domain, a BACK domain, and multiple Kelch motifs that form a β-propeller structure[2][4]. KLHL29 functions as a substrate adaptor within the Cullin 3 E3 ubiquitin ligase complex, mediating the ubiquitination and proteasomal degradation of specific target proteins, such as the RNA-binding protein DDX3X[1][3]. In triple-negative breast cancer, KLHL29 acts as a tumor suppressor: its expression is downregulated in tumor tissues, and its loss promotes proliferation, migration, and invasion of cancer cells, while restoration suppresses these aggressive cellular behaviors and cell cycle progression[1]. The broader KLHL family participates in diverse cellular processes, including mitotic progression, DNA repair, autophagy, and cytoskeletal organization, through their roles as E3 ligase adaptors[2]. No clinically approved drugs or targeted therapies are known to modulate KLHL29 activity, and its utility as a biomarker or therapeutic target is not established[3].

Other names

Kelch-like family member 29KBTBD9KIAA1921Kelch repeat and BTB domain-containing protein 9kelch-like 29