Kelch-like protein 4 (KLHL4)

Kelch-like protein 4 (KLHL4) is a cytoskeletal-associated protein encoded on the X chromosome, containing six Kelch repeats and a BTB/POZ domain, typical of its family[1][4][7]. These domains facilitate protein-protein interactions, including dimerization and adapter functions for ubiquitin ligases[3][4]. KLHL4 is expressed in several fetal tissues, including tongue and palate, and has been associated with congenital X-linked cleft palate (CPX)[4]. It mediates interactions with Cul3 E3 ligase and is shown to regulate cell-cycle progression by activating transcription of p21 through enhancement of p53 pathway activity[2][4]. Although the precise biological function is still under investigation, KLHL4 and its family members play roles in cytoskeletal organization, gene expression, and protein ubiquitination[3][7]. No drugs, biomarkers, or therapeutic safety data are currently associated with KLHL4, reflecting its status as a non-canonical drug target as of 2024[2][3][7].

Other names

KLHL4KIAA1687kelch-like family member 4KHL4DKELCHLkelch-like protein 4