Kelch-like protein 42 (KLHL42)

Kelch-like protein 42 (KLHL42) is a substrate-specific adaptor of the BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which is necessary for mitotic progression and cytokinesis[3][4][5]. The BCR(KLHL42) E3 ubiquitin ligase complex specifically mediates the ubiquitination and subsequent degradation of KATNA1, influencing microtubule dynamics throughout mitosis[5]. KLHL42 has a role in proteasome-mediated ubiquitin-dependent protein catabolic processes and the regulation of microtubule-based processes. Mutations in KLHL42 have been associated with Bardet-Biedl syndrome and Eiken syndrome[3]. The protein contains conserved domains characteristic of the Kelch-like gene family, specifically a BTB/POZ domain, a BACK domain, and Kelch repeats, and functions in assembling multiprotein E3 ubiquitin ligase complexes[1][3].

Other names

Kelch like family member 42KLHL42KLHDC5 (previous symbol)

Drugs would typically act by modulating ubiquitination, affecting downstream protein stability and degradation