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Target intelligence / Profile preview
Kelch repeat and BTB domain-containing protein 3 (KBTBD3)
- Target
- KBTBD3
- Molecular classification
- Other (BTB-Kelch family protein), Ubiquitin ligase substrate adaptor (putative; via Cul3-RING E3 ubiquitin ligase complex)[5][7], Scaffold protein
01
Overview
Kelch repeat and BTB domain-containing protein 3 (KBTBD3) is a protein encoded by the human KBTBD3 gene located on chromosome 11. It is a member of the BTB-Kelch protein family, containing a BTB/POZ (Broad-Complex, Tramtrack and Bric à brac/Poxvirus and zinc finger) domain, a BACK domain, and five kelch repeats. Proteins in this family often participate as substrate adaptors in Cullin-3-based E3 ubiquitin ligase complexes, facilitating ubiquitin-dependent protein degradation. While KBTBD3 is predicted to act as a ubiquitin ligase substrate adaptor component of the Cul3-RING ubiquitin ligase complex and may participate in proteasomal degradation pathways, its specific biological function remains uncharacterized. No validated disease associations or therapeutic targeting evidence currently exist, and no drugs or established biomarkers are known for this target[3][5][7][10].
- Other names
- BKLHD3BTB and kelch domain-containing protein 3Kelch repeat and BTB (POZ) domain containing 3BTB and kelch domain containing 3Epididymis secretory sperm binding protein
02
Biological functions
Predicted ubiquitin-like ligase-substrate adaptor activity[5][10]Proteasome-mediated, ubiquitin-dependent protein catabolic process (predicted)[5][7][10]Transcriptional regulation via chromatin structure control (by family association)[1][2]Component of the Cul3-RING ubiquitin ligase complex (predicted)[5][7]
03
Disease associations
No direct or validated roles in human disease established to date; possible prediction/association with "Schizotypal Personality Disorder" in curated gene-disease resources (low evidence)[5]
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