Kelch repeat and BTB domain-containing protein 7 (KBTBD7)

Kelch repeat and BTB domain-containing protein 7 (KBTBD7) is a member of the BTB-Kelch protein family, characterized by an N-terminal BTB domain, a C-terminal region with multiple Kelch repeats, and an internal BACK domain[1][2][8]. KBTBD7 functions both as a transcriptional activator and as a substrate adaptor for CUL3-based E3 ubiquitin ligase complexes[1][2][3][8]. As part of the CUL3-KBTBD7 complex, it facilitates the ubiquitination and proteasomal degradation of key signaling molecules such as the RAC1 regulator TIAM1 and the planar cell polarity core protein Vangl2, influencing cytoskeletal organization, cell migration, and proliferation[1][2][8]. KBTBD7 also regulates the Wnt/planar cell polarity pathway and is implicated in controlling breast cancer growth and metastasis, acting as a tumor suppressor in breast tissue[2]. Although it has not yet been validated as a direct therapeutic target and no drugs against it are known, its reduced expression is associated with poorer outcomes in breast cancer, suggesting a potential role as a prognostic biomarker[2].

Other names

Kelch repeat and BTB domain containing 7KBTBD7DKFZP434E2318BTB-kelch protein 7kelch repeat and BTB (POZ) domain containing 7

Not applicable (No drugs are currently known to target KBTBD7 specifically.)