Keloid fibroblast

Keloid fibroblasts are specialized connective tissue cells found in keloid scars, characterized by uncontrolled proliferation and excessive secretion of extracellular matrix components, especially type I and III collagen, in response to wound healing signals. Their abnormal function is driven by heightened sensitivity to profibrotic cytokines, primarily TGF-β, and altered expression of cell surface receptors and proteases like FAP. These cells are central to the pathogenesis of keloid disorder, which is a model of skin fibrosis[1][2][3][4][5][6]. Keloid fibroblast secretion function therefore describes a pathological process, not a pharmacological target or singular molecular entity.

Other names

Keloid-derived fibroblastKeloid scar fibroblastKF

Inhibition of growth factor signaling (e.g., anti-TGF-β)[2][3]; Inhibition of ECM synthesis; Induction of fibroblast apoptosis or senescence