Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Keratin, type I cuticular Ha3-II (KRT33B)
- Target
- KRT33B
- Molecular classification
- Intermediate filament protein, Structural protein, Cytoskeletal protein
01
Overview
Keratin, type I cuticular Ha3-II (KRT33B) is a member of the type I hair keratin gene family and encodes a structural protein that forms acidic intermediate filaments with type II keratins in hair and nails. The protein is expressed primarily in hair follicles and contributes to the structural integrity and resilience of hair shafts by forming heterodimers with type II keratins. Mutations or dysregulation of KRT33B may be associated with various hair and skin disorders. There are no known drugs directly targeting this protein, and it is not considered a therapeutic target but rather a structural component of epithelial cells
- Other names
- KRT33BHA3IIHa-3IIK33BKRTHA3AKRTHA3BhHa3-IIkeratin 33BHair keratin, type I Ha3-IIKeratin-33Bhard keratin type I 3II
02
Biological functions
Structural molecule activityEpithelial cell differentiationStructural constituent of skin epidermisHeterodimerization with type II keratins to form hair and nails
03
Disease associations
Associated with hair and nail disordersPotential links to eyelid carcinomaPotential links to skin pilomatrix carcinoma
Beyond the preview
Go deeper on Keratin, type I cuticular Ha3-II (KRT33B).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Keratin, type I cuticular Ha3-II (KRT33B).