Keratin, type I cytoskeletal 12 (KRT12)

Keratin 12 is a type I intermediate filament protein encoded by the KRT12 gene. It is specifically expressed in the corneal epithelium, where it forms heterodimers (intermediate filaments) with keratin 3, conferring resilience and structural integrity to the corneal surface[1][3][7]. KRT12 expression distinguishes the differentiated corneal and anterior limbal epithelial cells, and is regulated by transcription factors such as PAX6 and KLF4[3]. Mutations in the highly conserved domains of keratin 12 disrupt filament assembly, weakening the corneal epithelial barrier and resulting in Meesmann corneal dystrophy, a disease characterized by cyst formation, photophobia, and epithelial fragility[1][5][7]. There are no approved drugs targeting KRT12 directly. KRT12 genetic status serves as a diagnostic biomarker for inherited corneal dystrophies[1][3][5].

Other names

KRT12CK-12Cytokeratin-12Keratin-12K12Keratin 12, type IMeesmann corneal dystrophy protein (context: disease phenotype)

Not applicable; keratin 12 is not a drug target.