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Keratin, type I cytoskeletal 27 (KRT27)
- Target
- KRT27
- Molecular classification
- Intermediate filament protein, Type I cytoskeletal keratin, Structural protein
01
Overview
Keratin, type I cytoskeletal 27 (KRT27) is a member of the type I (acidic) keratin family, a subgroup of the intermediate filament superfamily of proteins[3][5][10]. It is primarily expressed in the inner root sheath of hair follicles, where it is essential for the proper assembly of type I and type II keratin complexes and the formation of keratin intermediate filaments, conferring structural stability to hair follicle cells[1][3]. Mutations or altered expression are associated with various hair disorders and some cancers, though KRT27 is not recognized as a therapeutic target or a biomarker in current clinical practice[1][3][5].
- Other names
- KRT27KRT25CCK-27K25CK27Cytokeratin-27Keratin-25CType I inner root sheath-specific keratin-K25irs3K25IRS3keratin 27, type Iinner root sheath-specific keratin K25irs3
02
Biological functions
Formation of keratin intermediate filamentsAssembly of type I and type II keratin complexesStructural integrity of the inner root sheath of hair follicles
03
Disease associations
Ovarian cancerLow grade gliomaUncombable hair syndromeRinged hair diseasePili bifurcatiWoolly hair (autosomal recessive and dominant forms)Hypotrichosis (simplex and types 4)Epidermolytic palmoplantar keratodermaTrichodysplasia-xeroderma syndromePili tortiMarie Unna hereditary hypotrichosisPili geminiMonilethrixHair defect with photosensitivity and intellectual disability syndrome
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