Keratin, type II cuticular Hb4 (KRT84)

Keratin, type II cuticular Hb4 (KRT84) is a type II hair keratin, part of the intermediate filament protein family that provides structural support to epithelial cells, particularly in hair and nails[1][2]. As a basic keratin, KRT84 heterodimerizes with type I keratins to form the structural framework of hair and nails. It is primarily expressed in hair follicles and also detected in the filiform papillae of the tongue[1][2]. Disease associations include Naegeli-Franceschetti-Jadassohn syndrome and palmoplantar keratoderma. This protein plays a structural role and is not a classical therapeutic target such as a receptor, enzyme, or transporter[1][5].

Other names

Keratin, type II cuticular Hb4KRT84KRTHB4K84Hb-4Keratin-84Type II hair keratin Hb4Type-II keratin Kb24hard keratin type II 4HB4keratin 84type IIkeratin, hair, basic, 4type II hair keratin 4type II hair keratin Hb4type-II keratin Kb24