Keratin, type II cuticular Hb6 (KRT86)

Keratin, type II cuticular Hb6 (KRT86) is a **structural protein** encoded by the *KRT86* gene and is a component of the intermediate filaments in the cortex of hair shafts and in other hard keratinized tissues such as nails[1][2][3][5]. This protein heterodimerizes with type I keratins to provide **mechanical strength** and **resilience** to the hair shaft, protecting it from everyday physical stress[2][1]. Mutations in *KRT86* are causative for **monilethrix**, a rare dominantly inherited hair disorder characterized by fragile, beaded hair and sometimes nail abnormalities[1][2][3]. The gene is not considered a classical pharmacological target, as it is a structural cytoskeletal protein rather than an enzyme, receptor, or transporter[1][3][5].

Other names

Keratin 86KRT86KRTHB6K86MNXHb6Hb1hHb6Keratin, hair, basic, 6 (monilethrix)Hair keratin K2.11Type II hair keratin Hb6Type-II keratin Kb26hard keratin type II 6KRTHB1

Not applicable; no direct pharmacological targeting reported