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Keratin, type II cytoskeletal 73 (KRT73)
- Target
- KRT73
- Molecular classification
- Structural protein, Intermediate filament, Cytoskeletal protein
01
Overview
Keratin, type II cytoskeletal 73 (KRT73) is a structural protein belonging to the type II keratin family of intermediate filament proteins, responsible for maintaining the structural integrity of epithelial cells. It is specifically expressed in the inner root sheath of hair follicles where it contributes to hair formation and the architecture of hair shaft-producing cells. The protein has a molecular weight of 58.9 kDa and an isoelectric point of 7.3. Human KRT73 is encoded on chromosome 12q13.3 and is grouped with other hair follicle-specific keratins; its closest paralog is KRT71. Mutations or disruption in KRT73 can be associated with disorders of hair texture, such as woolly hair.
- Other names
- Keratin 73K6IRS3KB36KRT6IRS3CK-73K73Cytokeratin-73Keratin-73Type II inner root sheath-specific keratin-K6irs3Type-II keratin Kb36IRT6IRS3keratin, type II cytoskeletal 73cytokeratin-73keratin 6 irs3keratin 73, type IItype II inner root sheath-specific keratin-K6irs3type-II keratin Kb36
02
Biological functions
Structural integrity of epithelial cellsHair formationComponent of keratin intermediate filaments in the inner root sheath of hair follicles
03
Disease associations
Woolly hair (autosomal dominant)Other hair follicle disorders
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