Keratin 17 pseudogene 5 (KRT17P5)

Keratin 17 pseudogene 5 (KRT17P5) is a genomic DNA sequence that resembles the keratin 17 gene but contains mutations (such as lack of an intact reading frame) that render it non-functional; it does not produce a protein and is classified as a pseudogene. Pseudogenes like KRT17P5 are generally regarded as nonfunctional genomic elements resulting from gene duplication or retrotransposition events. KRT17P5 is specifically listed in the HUGO Gene Nomenclature Committee (HGNC) as a pseudogene with locus type "Pseudogene". Pseudogenes such as KRT17P5 do not encode functional proteins and are generally not considered in molecular or disease mechanism studies. KRT17P5 is not to be confused with the functional KRT17 gene, which encodes keratin 17, a protein with important structural and pathological roles; only KRT17 (not KRT17P5) is implicated in diseases such as pachyonychia congenita and steatocystoma multiplex. KRT17P5 is not a protein-coding gene, not a therapeutic target, and has no known biological or clinical relevance beyond its annotation as a pseudogene.

Other names

Keratin 17 pseudogene 5KRT17P5