Keratin 18 pseudogene 11 (KRT18P11)

Keratin 18 pseudogene 11 (KRT18P11) is annotated as a pseudogene in the human genome and does not produce a functional protein. Pseudogenes arise from duplication or retrotransposition of functional genes and typically contain disabling mutations that prevent them from being expressed as active proteins. KRT18P11 is related in sequence to the keratin 18 (KRT18) gene, which encodes a type I intermediate filament protein important in epithelial cell structure and function, but KRT18P11 itself has no known biological, therapeutic, or disease-related roles. It is not considered a drug target, receptor, enzyme, or biomarker. Critical note: - The functional KRT18 gene is a widely studied cytoskeletal component and cancer biomarker[1][2][3][5]. In contrast, KRT18P11 is simply a non-functional genomic segment and should not be confused with Keratin 18 (KRT18); any translational or clinical significance associated with "keratin 18" does not apply to the pseudogene. - The naming conventions and database annotations for pseudogenes like KRT18P11 can cause confusion—recheck your intended target if you require a protein-coding, actionable molecular target. If you intended the functional cytokeratin, refer to "Keratin 18 (KRT18)," not KRT18P11.

Other names

KRT18L1keratin 18-like 1KRT18P11