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Keratin 18 pseudogene 16 (KRT18P16) is a processed pseudogene derived from the KRT18 gene, which encodes an intermediate filament protein critical for epithelial cell structure and has significance in several cancers. However, KRT18P16 itself does not encode a functional protein, has no known cellular or disease-related role, and is not considered a therapeutic target, biomarker, or drug interaction partner. As with other processed pseudogenes, it is a remnant of evolutionary gene duplication/retrotransposition and lacks an intact open reading frame and biological function[3][5].
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