Keratin 18 pseudogene 37 (KRT18P37)

Keratin 18 pseudogene 37 (KRT18P37) is a processed pseudogene derived from the KRT18 gene, part of the intermediate filament (keratin) gene family. Pseudogenes are non-functional sequences in the human genome, often arising from duplication or retrotransposition events but lacking the capacity to encode functional proteins due to missing regulatory elements or disruptive mutations. KRT18P37 does not participate in known cellular processes or disease mechanisms and is not a therapeutic drug target. Information regarding expression, interaction, or biological function is not available, as is typical for most pseudogenes. Keratin 18 (KRT18), the parent gene of this pseudogene, encodes a structural cytoskeletal protein that is clinically relevant as a diagnostic and prognostic marker in multiple cancers, and participates in cellular processes including apoptosis, cell cycle regulation, and signaling[1][2]. However, the pseudogene KRT18P37 does not share these properties[4][5]. The human genome contains numerous keratin pseudogenes; most lack intact reading frames and are considered nonfunctional[3][5]. In summary, KRT18P37 is not a receptor, enzyme, transporter, or therapeutic target. There is no evidence supporting its biological activity, disease involvement, or drug interactions[4][5][3].

Other names

Keratin 18 pseudogene 37KRT18P37

None applicable. Drugs do not target pseudogenes, including KRT18P37