keratin 18 pseudogene 48 (KRT18P48)

Keratin 18 pseudogene 48 is classified as a pseudogene in the human genome[5]. Pseudogenes are regions of DNA that resemble functional genes but are typically non-coding and lack protein production due to accumulated mutations or deletions. There is no evidence that KRT18P48 produces a functional protein, nor is it described in the literature as a therapeutic target, biomarker, or disease mediator[5]. The available information only confirms its classification as a pseudogene within molecular biology databases. The term "keratin 18 pseudogene 48" refers to a pseudogene and not an active protein, receptor, enzyme, or other therapeutic target. It is not considered actionable from a pharmacological or therapeutic perspective and has no established role in disease, function, or drug targeting[5]. Summary of key points: KRT18P48 is a pseudogene, not an active therapeutic or biomarker target. No documented biological functions, disease roles, or drug interactions. No established relevance for patient selection, efficacy monitoring, or safety concerns. The target may be incorrectly selected if the intention is to refer to an active protein, such as Keratin 18 (KRT18), which is a well-studied cytokeratin with established roles in biology and disease[1][3][4]. For reference, the canonical functional gene/protein in this family is "keratin 18" (KRT18), which is involved in cell structure, apoptosis, and is a biomarker in multiple cancers[1][4][3]. However, KRT18P48 does not encode the keratin 18 protein.

Other names

KRT18P48keratin 18 pseudogene 48