Keratin 18 pseudogene 65 (KRT18P65)

Keratin 18 pseudogene 65 (KRT18P65) is one of many *processed pseudogenes* derived from the gene encoding keratin 18 (KRT18), a cytoskeletal protein involved in the formation of intermediate filaments in simple epithelial cells[3][7]. Pseudogenes like KRT18P65 do not encode functional proteins and are typically inactive remnants derived from once-functional genes. The majority of human KRT18-related pseudogenes, including KRT18P65, are widespread across the genome as part of an unusually large repertoire of keratin 8 and 18 pseudogenes (almost 90% of keratin pseudogenes are linked to K8/K18)[3]. While some pseudogenes may play regulatory roles in gene expression or act as microRNA decoys in rare cases, there is no evidence that KRT18P65 has any biological, disease, or pharmacological role[3][6]. **Key clarifications:** - *KRT18P65 is a pseudogene, not a receptor, enzyme, transporter, or signaling target.* - *It is not a therapeutic target and is not known to have any function as a biomarker or in disease.* - *There is no evidence for direct interaction with any drug, nor is it used for diagnostic, prognostic, or predictive purposes.* **Note:** If you are interested in **keratin 18** (KRT18) itself, which is a functional structural protein with roles in epithelial biology and is used as a biomarker (e.g., M30, M65 fragments in cancer), or if this term ("KRT18P65") was meant to refer to something else, please specify for more detailed information about the canonical, functional keratin 18 rather than its pseudogenes[1][2][4][5]. In summary, **KRT18P65** should not be considered a therapeutic target or meaningful biological entity in the usual molecular biology, drug discovery, or clinical context.

Other names

Keratin 18 pseudogene 65KRT18P65