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Target intelligence / Profile preview
Keratin 19 pseudogene 3 (KRT19P3)
- Target
- KRT19P3
- Molecular classification
- Pseudogene, Type I keratin pseudogene
01
Overview
Keratin 19 pseudogene 3 (KRT19P3) is a non-protein-coding pseudogene highly homologous to the functional KRT19 (keratin 19) gene, located within the type I keratin gene family on chromosome 17. Unlike true keratin genes, KRT19P3 contains deletions and mutations (including frameshifts and premature termination codons), rendering it non-functional. Its main relevance is as a source of potential analytical error in diagnostic assays (RT-PCR) for cancer, because it may be mistaken for KRT19 mRNA in blood or tissue samples, resulting in false positive detection of micrometastatic disease[4][8]. There is no evidence that KRT19P3 has any structural, enzymatic, or receptor function, nor is it considered a therapeutic target.
- Other names
- Keratin 19 pseudogene 3KRT19P3Cytokeratin 19 pseudogene 3
02
Biological functions
May act as a genomic sequence with regulatory potential, such as miRNA decoy in rare reported cases for other pseudogenesNo direct protein-coding or structural function
03
Disease associations
Can interfere with molecular assays (RT-PCR) for micrometastasis detection because it shares sequence similarity with keratin 19, potentially causing false positive results in cancer diagnostics
04
Biomarkers
Pseudogene sequences can confound detection of the true KRT19 transcript, affecting the specificity of analyses such as tumor cell detection
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