Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Keratin 20 (CK20)
- Target
- CK20
- Molecular classification
- Intermediate filament protein, Cytoskeletal protein, Type I cytokeratin
01
Overview
Keratin 20 is a type I cytokeratin and intermediate filament protein encoded by the KRT20 gene. It is primarily expressed in mature enterocytes and goblet cells of the gastric and intestinal mucosa, as well as in urothelium, bladder, and Merkel cells. It plays a crucial structural role in maintaining the integrity of epithelial cells and is involved in organizing intermediate filaments in intestinal epithelia. Keratin 20 shows restricted tissue distribution and serves as a reliable marker for the differentiation state of epithelial cells, especially in the gastrointestinal tract. Its expression patterns are widely used as diagnostic and prognostic markers in several cancers, including colorectal and urothelial carcinomas. However, it is not considered a direct therapeutic target such as a receptor, enzyme, or transporter.
- Other names
- Cytokeratin 20KRT20CK20K20Keratin-20
02
Biological functions
Structural integrity of epithelial cellsMaintenance of intermediate filament organizationMarker of epithelial differentiation
03
Disease associations
Cancer (especially colorectal, gastric, and urothelial carcinomas)Other (serves as a histological marker for tumor classification)
04
Safety considerations
Not a therapeutic target; safety concerns relate to diagnostic reliability rather than therapy
05
Biomarkers
Histological marker for identifying and classifying gastrointestinal, urothelial, and Merkel cell carcinomasDiagnostic/prognostic marker in colorectal cancer (e.g. CK7–/CK20+ phenotype)
Beyond the preview
Go deeper on Keratin 20 (CK20).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Keratin 20 (CK20).