Keratin, type II cytoskeletal 4 (KRT4)

Keratin, type II cytoskeletal 4 (KRT4), is a structural protein classified as a type II cytokeratin predominantly expressed in the differentiated (suprabasal) cells of moist, non-cornified epithelial tissues, such as the oral mucosa, esophagus, and certain other mucous membranes. It forms stable heterodimers, especially with keratin 13 (KRT13), to create intermediate filaments that provide mechanical strength and protection from frictional damage. Mutations in the KRT4 gene are associated with the hereditary condition White Sponge Nevus, resulting in thickened, white, sponge-like oral lesions due to defective structural support in mucosal epithelia. There are currently no therapeutic drugs specifically targeting KRT4, and it is not considered a classical drug target such as a receptor, enzyme, or transporter. Note: KRT4 is not a therapeutic target but is important in diagnostics for specific mucosal diseases such as White Sponge Nevus. It is primarily of clinical significance as a biomarker and a component of structural pathology in certain genetic diseases.

Other names

CK-4CK4CYK4K4WSN1keratin-4cytokeratin 4Cytokeratin-4keratin, type II cytoskeletal 4Type-II keratin Kb4KRT4