Keratin 41 pseudogene (KRT41P)

Keratin 41 pseudogene (KRT41P) is part of the human type I hair keratin gene cluster but is inactivated in humans by a single base-pair substitution introducing a premature stop codon in exon 4, leading to loss of function[1][7][2]. While its ortholog encodes a functional hair keratin protein in nonhuman primates such as chimpanzees and gorillas, the human version is the product of a recent mutational event and does not encode a protein[1][7]. Its inactivation may have contributed to differences in hair structure between humans and great apes, though specific functional consequences are unknown[1]. KRT41P is catalogued and named according to the consensus keratin pseudogene nomenclature[2][7]. It is not a molecular therapeutic target, nor does it participate in pathways or processes of clinical interest in humans.

Other names

phihHaAHHaAKRTHAP1keratin 38 pseudogenekeratin, hair, acidic pseudogene 1KRT41P