Keratin 8 pseudogene 18 (KRT8P18)

Keratin 8 pseudogene 18 (KRT8P18) is classified as a pseudogene related by sequence to the keratin 8 gene. It does not code for a functional protein and has no known biological function, disease associations, or role as a drug target. Its existence is primarily noted in genomic studies and gene annotation resources as a non-functional DNA sequence sharing homology with the protein-coding keratin genes.[4] KRT8P18 is not a receptor, enzyme, transporter, or target in therapeutic development. It is often listed in gene databases, but no protein or functional role is associated with it[4]. Its parent gene, keratin 8 (KRT8), has critical roles in cytoskeletal integrity in epithelial cells, liver disease, and can be a biomarker in pathology, but this does not apply to KRT8P18[5][7]. Pseudogenes like KRT8P18 are generally not involved in cellular function or disease except in rare cases where they may act as regulatory RNAs, and there is no such evidence for KRT8P18. In summary, Keratin 8 pseudogene 18 (KRT8P18) is not a therapeutic target, has no known biological or disease relevance, and is best classified as a non-functional pseudogene[4].

Other names

KRT8P18keratin 8 pseudogene 18