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Keratin 8 pseudogene 21 (KRT8P21) is a processed, noncoding pseudogene in the human genome belonging to the keratin pseudogene family. Unlike the protein-coding keratin 8 gene (KRT8), which encodes a cytoskeletal intermediate filament protein, KRT8P21 does not produce a functional protein and has no established biological, disease, or therapeutic relevance. Its designation is solely based on sequence similarity to KRT8 and its classification as a pseudogene based on the consensus nomenclature for mammalian keratins[3].\n\nKRT8P21 is not mentioned in canonical protein, functional gene, or therapeutic target databases, and its "21" designation is part of an extended pseudogene numbering system; processed keratin pseudogenes are abundant in the human genome, particularly those related to keratin 8[3]. No known literature describes biological function, disease association, or drug interactions for KRT8P21.
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