Keratin and intercellular lipid in stratum corneum

Keratin and intercellular lipid in the stratum corneum are not individual molecular drug targets but essential structural components of the outermost skin layer, forming the major **barrier system of skin**. **Keratin** is a structural protein in corneocytes (flattened dead skin cells), providing mechanical strength and water-binding capacity[3][4]. **Intercellular lipids** (mainly ceramides, cholesterol, and free fatty acids) fill the spaces between corneocytes as a “mortar” in a brick-and-mortar model, preventing water loss and entry of pathogens or chemicals[4][3]. The integrity and organization of both keratin filaments and lipid layers are crucial for maintaining barrier properties, hydration, and defence against environmental hazards. Disruption of this balance is associated with various skin disorders (e.g., eczema, psoriasis), and topical therapies often aim to restore or protect these structural elements[4][3]. **Note**: "Keratin and intercellular lipid in stratum corneum" refers to a composite matrix, not a discrete receptor, enzyme, or protein target. It may be too general/incorrect as a "therapeutic target" per the usual pharmacological definition.

Other names

Stratum corneum keratin and lipidSC keratin and lipidCorneocyte keratin and lipid matrix

Restoration of lipid matrix (replacement creams); Occlusion and hydration (emollients, moisturizers); Disruption of protein/lipid matrix (keratolytics, surfactants); Modulation of keratinocyte turnover (retinoids)