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Target intelligence / Profile preview
Keratin-associated protein 10-1 (KRTAP10-1)
- Target
- KRTAP10-1
- Molecular classification
- Other, Keratin-associated protein, High sulfur KAP family
01
Overview
Keratin-associated protein 10-1 (KRTAP10-1) is a member of the high sulfur keratin-associated protein (KAP) family, encoded by an intronless gene on human chromosome 21q22.3[1][2][7]. KRTAP10-1 is an essential structural component of hair fibers, forming an interfilamentous matrix around keratin intermediate filaments in the hair cortex and contributing to the rigidity and resilience of the hair shaft[1][2][4]. These proteins contain abundant cysteine residues, enabling extensive disulfide cross-linking with hair keratins, which is critical for the mechanical properties of hair[4]. KRTAP10-1 shows high expression in hair and possibly related epithelial tissues, but is not considered a drug target, receptor, enzyme, or therapeutic target in current biomedical literature[1][2][3][4].
- Other names
- KAP10.1KAP18.1KRTAP10.1KRTAP18-1KAP18-1KRTAP18.1Keratin-associated protein 18-1Keratin-associated protein 18.1High sulfur keratin-associated protein 10.1
02
Biological functions
Hair and epithelial keratin synthesisStructural component of hair fibersForms interfilamentous matrix for keratin intermediate filaments
03
Disease associations
Other (No strong or direct disease link; some mentions in syndromic context without established causality)
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