Keratin-associated protein 10-11 (KRTAP10-11)

Keratin-associated protein 10-11 (KRTAP10-11) is a structural protein of the KAP family, predominantly expressed in the hair cortex where it interacts with keratin intermediate filaments to provide mechanical strength and rigidity to hair fibers. This function is mediated by extensive disulfide cross-linking with cysteine-rich regions in keratin proteins, contributing to the biomechanical and biochemical properties of hair, including fiber thickness and resistance[1][3][5]. The KRTAP10 family is notable for its high sulfur content, classifying members like KRTAP10-11 among the "high sulfur" keratin-associated proteins[1][2][3], and its gene is located within a major cluster of KAP genes on chromosome 21. The protein is not considered a therapeutic target (i.e., not a receptor, enzyme, transporter, or major drug-interacted protein), and there are currently no known direct pharmacological agents or biomarkers associated with KRTAP10-11[1][5]. There is no evident error or confusion with the molecular identity; the main aliases and cross-references are generally consistent in public bioinformatic resources.

Other names

KAP10.11KAP18-11KRTAP18-11KRTAP18.11KAP18.11KAP10-11KAP10.9KRTAP10-9KRTAP10.9KRTAP18-9KRTAP18.9Keratin-associated protein 18-11Keratin-associated protein 18.11High sulfur keratin-associated protein 10.11High sulfur keratin-associated protein 10.9