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Keratin-associated protein 10-2 (KRTAP10-2)
- Target
- KRTAP10-2
- Molecular classification
- Other (structural hair matrix protein), not an enzyme, receptor, transporter, or signaling molecule
01
Overview
Keratin-associated protein 10-2 (KRTAP10-2) is a member of the high sulfur-type keratin-associated protein (KAP) family, which forms the interfilamentous matrix surrounding keratin intermediate filaments in the hair cortex[1][5][11]. Through extensive disulfide bond cross-linking, these proteins contribute to the formation of a rigid and resistant hair shaft. The gene is located in a cluster of similar genes on chromosome 21q22.3. KRTAP10-2 is not classified as a therapeutic target, such as a druggable receptor or enzyme, but rather serves a structural role in hair fiber formation and integrity[1][5][7][11]. No drugs are known to target this protein, and it is not associated with established disease roles or use as a clinical biomarker.
- Other names
- KAP10.2KAP18.2KRTAP18-2KRTAP10.2KRTAP18.2high sulfur keratin-associated protein 10.2keratin-associated protein 18-2keratin-associated protein 18.2
02
Biological functions
Structural component of hairforms a matrix with keratins to impart rigidity and strength to the hair shaft via extensive disulfide cross-linking
03
Disease associations
None established as a primary disease driverassociated with monogenic disorders only indirectly (e.g., related to hair/fiber structure or rare congenital syndromes in database correlations, not mechanistically)
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