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Keratin-associated protein 10-5 (KRTAP10-5)
- Target
- KRTAP10-5
- Molecular classification
- Other (structural protein, keratin-associated protein, high-sulfur subgroup)
01
Overview
Keratin-associated protein 10-5 (KRTAP10-5) is a member of the keratin-associated protein family. It is a protein-coding gene located on chromosome 21. The proteins encoded by KRTAP genes form disulfide cross-links with cysteine residues of hair keratins, providing mechanical strength, rigidity, and stability to hair fibers[1]. KRTAP10-5 belongs to the high-sulfur subgroup of keratin-associated proteins and is found in the matrix embedding hair keratin filaments in the hair cortex[1][3]. These proteins are not considered classical therapeutic targets, but they play a substantial role in hair development and morphology. There are no established drugs that directly interact with KRTAP10-5, and it is not a known biomarker or safety concern for therapeutics[1][3][4].
- Other names
- KAP10.5KAP18-5KRTAP10.5KRTAP18-5KRTAP18.5Keratin-associated protein 18-5High sulfur keratin-associated protein 10.5
02
Biological functions
Contributes to structure and stability of hair fibers by forming disulfide bonds with cysteine residues in hair keratinsinvolved in keratinization (hair shaft formation)
03
Disease associations
Nodular basal cell carcinomaFrontometaphyseal dysplasia (association reported with keratinization pathway genes but not causally established)
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