Keratin-associated protein 10-6 (KRTAP10-6)

Keratin-associated protein 10-6 (KRTAP10-6) is a member of the keratin-associated protein (KRTAP) family, characterized by a high content of cysteine residues and classified within the high-sulfur KRTAP subfamily. It is a structural protein localized in the hair cortex, where it forms a matrix embedding hair keratin intermediate filaments. Through extensive disulfide bonding, KRTAP10-6 contributes to the rigidity and resistance of the hair shaft. KRTAP10-6 is primarily relevant for the biophysical properties of hair, influencing attributes like strength and resilience but is not considered a therapeutic target for drugs or disease intervention. No pharmaceuticals are known to target this protein, and it is not commonly used as a clinical biomarker. KRTAP10-6 is a structural matrix protein in hair, crosslinking with keratin filaments in the hair cortex via disulfide bonds. It is classified as a high-sulfur KRTAP due to its high cysteine content, which is crucial for its role in hair rigidity. Disease association is minimal and largely limited to rare syndromic connections rather than common pathology. The nomenclature and aliases reflect its classification within the large and diverse KRTAP gene family. There is no indication in scientific resources or databases that KRTAP10-6 is a therapeutic target or druggable protein.

Other names

Keratin-associated protein 10-6KRTAP10-6KAP10.6KAP18-6KRTAP10.6KRTAP18-6KRTAP18.6KAP18.6High sulfur keratin-associated protein 10.6Keratin-associated protein 18-6