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Target intelligence / Profile preview
Keratin-associated protein 12-3 (KRTAP12-3)
- Target
- KRTAP12-3
- Molecular classification
- Other (specifically, keratin-associated protein)
01
Overview
Keratin-associated protein 12-3 (KRTAP12-3) is a member of the keratin-associated protein (KAP) family, specifically falling within the "high sulfur" group due to its high content of sulfur-rich amino acids such as cysteine. These proteins are primarily expressed in the hair follicle cortex, where they tightly associate with keratin intermediate filaments to contribute to the structure, stability, and properties of hair fibers. KRTAP12-3 is not classified as a receptor, enzyme, transporter, or classic therapeutic target, but rather acts as a structural protein. Defects in keratin-associated proteins can affect hair texture, strength, and appearance, but specific disease associations for KRTAP12-3 have not been documented in the current biomedical literature[3].
- Other names
- KAP12.3KRTAP12.3high sulfur keratin-associated protein 12.3keratin-associated protein 12.3
02
Biological functions
Structural component of hair and possibly nailsContributes to the formation and mechanical properties of keratin filaments in hair cortex
03
Disease associations
Other (currently no well-established or direct disease association as seen with some other keratin or keratin-associated proteins)
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