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Target intelligence / Profile preview
Keratin-associated protein 13-1 (KRTAP13-1)
- Target
- KRTAP13-1
- Molecular classification
- Structural protein, Keratin-associated protein, Other
01
Overview
Keratin-associated protein 13-1 (KRTAP13-1) is a high-sulfur structural protein found in the hair cortex, where hair keratin intermediate filaments are embedded in a matrix of keratin-associated proteins. KRTAP13-1 stabilizes and strengthens the hair shaft by forming extensive disulfide bonds with abundant cysteine residues of hair keratin proteins[2][3][5]. Its role is primarily in hair fiber development and quality, particularly in sheep and humans, and it is not considered a therapeutic drug target. Genetic variation in related KRTAP13 family genes can influence fiber traits in wool, though KRTAP13-1 itself has not shown such associations[1][2].
- Other names
- KRTAP13-1KAP13.1Keratin-associated protein 13.1High sulfur keratin-associated protein 13.1KRTAP13.1
02
Mechanism of action
Not applicable (no drugs target this protein)
03
Biological functions
Structural component of hair fibersContributes to hair shaft rigidity and resistance via disulfide bond cross-linking
04
Disease associations
Other (No evidence implicating direct roles in major diseases; studied in relation to hair/wool traits, not pathogenesis)
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