Keratin-associated protein 13-3 (KRTAP13-3)

Keratin-associated protein 13-3 (KRTAP13-3) is a structural protein found predominantly in hair and wool fibers, where it is an important component of the matrix surrounding keratin intermediate filaments[1][2][4][6][8]. KRTAP13-3 belongs to the family of high-sulphur keratin-associated proteins (KAPs), characterized by a high cysteine content, enabling extensive disulfide bonds with keratins and contributing to the rigidity and strength of hair and wool fibers[1][4][8]. KRTAP13-3 has species-specific variants and polymorphisms that can influence the physical attributes of the fibers, such as their mechanical properties and quality, especially in livestock where fiber properties are an important economic trait[1][5]. It is not a therapeutic target and there are no known drugs or biomarkers associated with it. It is classified as a structural protein rather than a receptor, enzyme, or other therapeutic class. Its function is primarily in the determination of fiber characteristics in mammals[1][2][6][8].

Other names

KRTAP13-3KAP13.3keratin associated protein 13-3